Hydrazones have been reported as possible new antimicrobial, antitubercular, anticonvulsant, antiinflamatory, antitumoral and antiviral agents. In this project we aim the development of hydrazides and hydrazones derivatives of commercial drugs such as antimicrobial compounds (e.g. nalidixic acid) and NSAIDs (e.g. ibuprofen). These hydrazides/hydrazones will be further studied as potencial ligands for several metal ions and their antimicrobial and antitumoral ativities will be evalutated as free ligands as well as coordination entities.